A comprehensive map of how Alzheimer's affects the brain

MIT researchers have performed the first comprehensive analysis of the genes that are expressed in individual brain cells of patients with Alzheimer's disease. The results allowed the team to identify distinctive cellular pathways that are affected in neurons and other types of brain cells.

This analysis could offer many potential new drug targets for Alzheimer's, which afflicts more than 5 million people in the United States.

"This study provides, in my view, the very first map for going after all of the molecular processes that are altered in Alzheimer's disease in every single cell type that we can now reliably characterize," says Manolis Kellis, a professor of computer science and a member of MIT's Computer Science and Artificial Intelligence Laboratory and of the Broad Institute of MIT and Harvard. "It opens up a completely new era for understanding Alzheimer's."

The study revealed that a process called axon myelination is significantly disrupted in patients with Alzheimer's. The researchers also found that the brain cells of men and women vary significantly in how their genes respond to the disease.


https://www.sciencedaily.com/releases/2019/05/190501131400.htm

I think its time some people on here. Instead of placing dogmatic faith in miracle cures they read on the web from charlatans out to actually harm people with their lies. Actually start listening to scientists. That daily, exhaust all avenues to help cure people.

What I would like to know is why Alzheimers seems more prevalent now and why does it affect people so early? I don't remember so many people being affected, some used to succumb to senility but most died unaffected. Is it because we are living longer but how does that work with younger people getting it if its age related, is it then the environment we live in with far more chemicals being used in our everyday life. I only had one set of grandparents that I knew who died in their 80's with no sign of any kind of dementia, my uncles and aunts lived long lives and died without this problem. What's going on?