How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
3 posters
Page 1 of 1
How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
Revealed: How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
Scientists have finally identified how sugar feeds cancer in a new research paper which has been hailed as a 'breakthrough'.
The study, published today, explains why cancer cells rapidly break down sugars without producing much energy - a phenomenon discovered in 1920, dubbed the 'Warburg effect'.
Until now, it hasn't been clear whether the effect was a symptom of cancer, or a cause.
But a nine-year joint research project conducted by a coalition of Dutch universities has shown that sugar naturally connects with a gene called 'ras', which is essential to each cancer cell's ability to survive.
This connection traps cancer so forcefully that cells are powerless to expel it, creating a 'vicious cycle' that stimulates the cancer and persistently metabolizes the sugar.
The finding published in Nature Communications could have implications for cancer patients' diets, and for non-sufferers it sheds further light on the dangers of sugar.
'Our research reveals how the hyperactive sugar consumption of cancerous cells leads to a vicious cycle of continued stimulation of cancer development and growth,' said lead author Professor Johan Thevelein, a molecular biologist at VIB and KU Leuven.
'Thus, it is able to explain the correlation between the strength of the Warburg effect and tumor aggressiveness.
'This link between sugar and cancer has sweeping consequences.
'Our results provide a foundation for future research in this domain, which can now be performed with a much more precise and relevant focus.'
However, they still have no idea why the aggressive disease hasn't evolved out of this fruitless process.
The research began in 2008.
The objective was to shed light on the Warburg effect, which was discovered by Otto Warburg, a German physicist, in 1920.
Dr Warburg found that convert significantly higher amounts of sugar into lactate compared to healthy tissues.
For some reason, healthy cells gain significantly energy from sugar than cancer cells do.
Dr Warburg wasn't able to explain this conundrum - nor was any other researcher in the years since.
That is why this research paper has been lauded as such a significant step in understanding cancer.
The researchers studied yeast, which contain the same 'ras' gene as cancer cells.
Professor Johan Thevelein explained: 'We observed in yeast that sugar degradation is linked via the intermediate fructose 1,6-biophosphate to the activation of Ras proteins, which stimulate the multiplication of both yeast and cancer cells.
'It is striking that this mechanism has been conserved throughout the long evolution of yeast cell to human.
'The main advantage of using yeast was that our research was not affected by the additional regulatory mechanisms of mammalian cells, which conceal crucial underlying processes.
'We were thus able to target this process in yeast cells and confirm its presence in mammalian cells.
'However, the findings are not sufficient to identify the primary cause of the Warburg effect.
'Further research is needed to find out whether this primary cause is also conserved in yeast cells.'
http://www.dailymail.co.uk/health/article-4986706/How-sugar-feeds-cancer-makes-harder-treat.html
- In 1920, a German scientists called Dr Otto Warburg discovered that cancer cells rapidly break down sugars without producing much energy
- To this day we still don't understand the phenomenon - known as the Warburg effect
- But now a nine-year study has identified how sugar traps cancer in a 'vicious cycle' making it more aggressive and harder to treat
- The findings could have implications for the diets of cancer sufferers
Scientists have finally identified how sugar feeds cancer in a new research paper which has been hailed as a 'breakthrough'.
The study, published today, explains why cancer cells rapidly break down sugars without producing much energy - a phenomenon discovered in 1920, dubbed the 'Warburg effect'.
Until now, it hasn't been clear whether the effect was a symptom of cancer, or a cause.
But a nine-year joint research project conducted by a coalition of Dutch universities has shown that sugar naturally connects with a gene called 'ras', which is essential to each cancer cell's ability to survive.
This connection traps cancer so forcefully that cells are powerless to expel it, creating a 'vicious cycle' that stimulates the cancer and persistently metabolizes the sugar.
The finding published in Nature Communications could have implications for cancer patients' diets, and for non-sufferers it sheds further light on the dangers of sugar.
'Our research reveals how the hyperactive sugar consumption of cancerous cells leads to a vicious cycle of continued stimulation of cancer development and growth,' said lead author Professor Johan Thevelein, a molecular biologist at VIB and KU Leuven.
'Thus, it is able to explain the correlation between the strength of the Warburg effect and tumor aggressiveness.
'This link between sugar and cancer has sweeping consequences.
'Our results provide a foundation for future research in this domain, which can now be performed with a much more precise and relevant focus.'
However, they still have no idea why the aggressive disease hasn't evolved out of this fruitless process.
The research began in 2008.
The objective was to shed light on the Warburg effect, which was discovered by Otto Warburg, a German physicist, in 1920.
Dr Warburg found that convert significantly higher amounts of sugar into lactate compared to healthy tissues.
For some reason, healthy cells gain significantly energy from sugar than cancer cells do.
Dr Warburg wasn't able to explain this conundrum - nor was any other researcher in the years since.
That is why this research paper has been lauded as such a significant step in understanding cancer.
The researchers studied yeast, which contain the same 'ras' gene as cancer cells.
Professor Johan Thevelein explained: 'We observed in yeast that sugar degradation is linked via the intermediate fructose 1,6-biophosphate to the activation of Ras proteins, which stimulate the multiplication of both yeast and cancer cells.
'It is striking that this mechanism has been conserved throughout the long evolution of yeast cell to human.
'The main advantage of using yeast was that our research was not affected by the additional regulatory mechanisms of mammalian cells, which conceal crucial underlying processes.
'We were thus able to target this process in yeast cells and confirm its presence in mammalian cells.
'However, the findings are not sufficient to identify the primary cause of the Warburg effect.
'Further research is needed to find out whether this primary cause is also conserved in yeast cells.'
http://www.dailymail.co.uk/health/article-4986706/How-sugar-feeds-cancer-makes-harder-treat.html
HoratioTarr- Forum Detective ????♀️
- Posts : 10037
Join date : 2014-01-12
Re: How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
Most people who have amazing cancer stories to tell - like beating the odds after being told to literally go home and die - stopped eating all refined sugars and processed foods.
Sugar is one of the worst things you can put in your body. Yet stupidly, I do allow myself it in the form of chocolate and cheesecakes.
Sugar is one of the worst things you can put in your body. Yet stupidly, I do allow myself it in the form of chocolate and cheesecakes.
eddie- King of Beards. Keeper of the Whip. Top Chef. BEES!!!!!! Mushroom muncher. Spider aficionado!
- Posts : 43129
Join date : 2013-07-28
Age : 25
Location : England
Re: How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
It has been recognised for a while that the three worst constituents in over-refined foods, especially junk foods, are the three "white and deadlies" :
* Animal fats (plus Palm oil, and some processed vege' oils..)
* Refined (white) sugar, and increasingly these days 'HFCS' (high-fructose corn syrup..)
* Refined (white) flour.
While the part that excessive sugar consumption plays in ill health is important, high animal fat intake is still a major cause of heart disease, obesity and cancers, while a lack of fibre in the diet doesn't help either..
'Wolfie- Forum Detective ????♀️
- Posts : 8189
Join date : 2016-02-24
Age : 66
Location : Lake Macquarie, NSW, Australia
Re: How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
And yet I posted about this a few years back that processed foods and sugar feed cancer - but got told to stop it .
Guest- Guest
Re: How sugar feeds cancer and makes it harder to treat, according to 'breakthrough' study
Animal fats are fine its cooking oils that are bad . High fat low carb diets are healthy because they keep sugar content down .
I know this I am type 2 diabetic and only eat a low carb high fat diet and i have normal sugar readings .
I know this I am type 2 diabetic and only eat a low carb high fat diet and i have normal sugar readings .
Guest- Guest
Similar topics
» Two Breakthrough Drugs to Treat Migraines May Soon Hit the Market
» Oxford study finds virtual reality can help treat severe paranoia
» Frankincense may treat arthritis by attaching to the body's swollen areas and blocking inflammation, study says
» Oxford study: Climate change makes flooding more likely in England
» Study Suggests Riding Public Transport Makes You Less Prejudiced
» Oxford study finds virtual reality can help treat severe paranoia
» Frankincense may treat arthritis by attaching to the body's swollen areas and blocking inflammation, study says
» Oxford study: Climate change makes flooding more likely in England
» Study Suggests Riding Public Transport Makes You Less Prejudiced
Page 1 of 1
Permissions in this forum:
You cannot reply to topics in this forum
Sat Mar 18, 2023 12:28 pm by Ben Reilly
» TOTAL MADNESS Great British Railway Journeys among shows flagged by counter terror scheme ‘for encouraging far-right sympathies
Wed Feb 22, 2023 5:14 pm by Tommy Monk
» Interesting COVID figures
Tue Feb 21, 2023 5:00 am by Tommy Monk
» HAPPY CHRISTMAS.
Sun Jan 01, 2023 7:33 pm by Tommy Monk
» The Fight Over Climate Change is Over (The Greenies Won!)
Thu Dec 15, 2022 3:59 pm by Tommy Monk
» Trump supporter murders wife, kills family dog, shoots daughter
Mon Dec 12, 2022 1:21 am by 'Wolfie
» Quill
Thu Oct 20, 2022 10:28 pm by Tommy Monk
» Algerian Woman under investigation for torture and murder of French girl, 12, whose body was found in plastic case in Paris
Thu Oct 20, 2022 10:04 pm by Tommy Monk
» Wind turbines cool down the Earth (edited with better video link)
Sun Oct 16, 2022 9:19 am by Ben Reilly
» Saying goodbye to our Queen.
Sun Sep 25, 2022 9:02 pm by Maddog
» PHEW.
Sat Sep 17, 2022 6:33 pm by Syl
» And here's some more enrichment...
Thu Sep 15, 2022 3:46 pm by Ben Reilly
» John F Kennedy Assassination
Thu Sep 15, 2022 3:40 pm by Ben Reilly
» Where is everyone lately...?
Thu Sep 15, 2022 3:33 pm by Ben Reilly
» London violence over the weekend...
Mon Sep 05, 2022 2:19 pm by Tommy Monk
» Why should anyone believe anything that Mo Farah says...!?
Wed Jul 13, 2022 1:44 am by Tommy Monk
» Liverpool Labour defends mayor role poll after turnout was only 3% and they say they will push ahead with the option that was least preferred!!!
Mon Jul 11, 2022 1:11 pm by Tommy Monk
» Labour leader Keir Stammer can't answer the simple question of whether a woman has a penis or not...
Mon Jul 11, 2022 3:58 am by Tommy Monk
» More evidence of remoaners still trying to overturn Brexit... and this is a conservative MP who should be drummed out of the party and out of parliament!
Sun Jul 10, 2022 10:50 pm by Tommy Monk
» R Kelly 30 years, Ghislaine Maxwell 20 years... but here in UK...
Fri Jul 08, 2022 5:31 pm by Original Quill