Vitamin C effective in targeting cancer stem cells

by HoratioTarr Tue Mar 21, 2017 11:54 pm

VITAMIN C is up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, according to scientists in Salford, UK.

The research, published in Oncotarget, is the first evidence that Vitamin C (ascorbic acid) can be used to target and kill cancer stem cells (CSCs), the cells responsible for fuelling fatal tumours.

Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: “We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey-bee derivative, but by far the most exciting are the results with Vitamin C.

“Vitamin C is cheap, natural, non-toxic and readily available so to have it as a potential weapon in the fight against cancer would be a significant step.”

Seven substances

Cancer stem-like cells are thought to be the root cause of chemotherapy resistance, leading to treatment failure in patients with advanced disease and the triggers of tumour recurrence and metastasis (regrowth).

The Salford team set out to assess the bioenergetics of cancer stem cells - the processes which allow the cells to live and thrive – with a view to disrupting their metabolism.

Focusing on energy-transfer, they measured the impact on cell lines in a laboratory of 7 substances, the clinically-approved drug stiripentol, 3 natural products - caffeic acid phenyl ester (CAPE), silibinin and ascorbic acid - and experimental pharmaceuticals, such as actinonin, FK866 and 2-DG.

While they found that natural antibiotic actinonin and the compound FK866 were the most potent, the natural products also inhibited CSC formation, with Vitamin C, outperforming 2-DG by tenfold in terms of potency.

Evidence growing

Vitamin C has previously been shown to be effective as a non-toxic anti-cancer agent in studies by Nobel Prize winner Linus Pauling and was recently shown to reduce mortality by 25% on breast cancer patients in Japan. However, its effects on CSC activity have not been previously evaluated and in this context, it behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the “powerhouse” of the cell.

Dr Gloria Bonuccelli, lead author and another member of the Salford team added: “This is further evidence that Vitamin C and other non-toxic compounds may have a role to play in the fight against cancer.

“Our results indicate it is a promising agent for clinical trials, and a as an add-on to more conventional therapies, to prevent tumour recurrence, further disease progression and metastasis.”

Authors:

Gloria Bonuccelli, Ernestina Marianna De Francesco, Rianne de Boer, Herbert B. Tanowitz and Michael P. Lisanti.

http://www.salford.ac.uk/news/articles/vitamin-c-effective-in-targeting-cancer-stem-cells

by Victorismyhero Wed Mar 22, 2017 9:25 am

This has been mooted in the past...and dismissed. Perhaps its time for it to be re-evaluated seriously, even if not a "cure" (as we discussed in another thread) It may well be that in conjunction with other therapy it will will act as an adjuvent, to potentise without increasing the toxicity, of the main treatment.....I doubt seriously that ON ITS OWN it will have a place as a direct anti cancer agent, but as they say...every little helps.

by HoratioTarr Wed Mar 22, 2017 10:07 am

Lord Foul wrote:This has been mooted in the past...and dismissed. Perhaps its time for it to be re-evaluated seriously, even if not a "cure" (as we discussed in another thread) It may well be that in conjunction with other therapy it will will act as an adjuvent, to potentise without increasing the toxicity, of the main treatment.....I doubt seriously that ON ITS OWN it will have a place as a direct anti cancer agent, but as they say...every little helps.

I think it might have been Eddie who posted something about Vit. C and cancer on here? It was ridiculed by the usual suspects.

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